A Review Article on the Phytochemical Investigation and Anti-Cancer Activity of Vitex Negundo

Author

Ben Samuel J, Dr. S. Jebaseelan


Abstract

 The ethanolic extract of Vitex trifolia has been investigated for its potential antitumor activity against Dalton’s ascites lymphoma (DAL) in a murine model. In the study, tumor-bearing mice were administered the extract orally at a dose of 400 mg/kg body weight for 14 consecutive days, with 5-fluorouracil (20 mg/kg) serving as the standard anticancer drug. The antitumor effect was evaluated by assessing body weight changes, packed cell volume (PCV), viable tumor cell count, lifespan, and hematological parameters, including red blood cell (RBC) and white blood cell (WBC) counts. The results demonstrated that treatment with the ethanolic extract significantly reduced body weight gain, PCV, and viable tumor cell count. Additionally, the extract prolonged the lifespan of tumor-bearing mice and improved hematological parameters toward normal levels. These changes were statistically significant compared with the control group (p < 0.01), indicating a protective effect against tumor-associated alterations. Overall, the findings suggest that V. trifolia possesses promising antitumor potential and may serve as a source of bioactive compounds for further anticancer research. However, additional studies are required to identify its active constituents, elucidate the underlying mechanisms, and establish its safety and therapeutic efficacy through further preclinical and clinical investigations.



Keywords

Vitex trifolia, Antitumor activity, Dalton’s ascites lymphoma, Ethanolic extract, Anticancer potential.



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References


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