Phytochemical and Pharmacological Properties of Piper Longum
Author
Gitesh Kumar, Akshay Kumar
Abstract
Piper longum L. is a plant that belongs to the Piperaceae family and has been used historically in food and traditional medicine in South Asian countries. Characterised by its spicy fruits, it can be used as a spice in cooking. It has been used historically in traditional herbal formulations using both the fruit and root. Research is being carried out due to its chemical diversity and biological activity shown in extracts and constituents within the plant. [1, 7, 10, 29]
Studies have shown that P. longum contains many different phytochemical groups including alkaloids and amides, lignans, flavonoids, volatile compounds and sterols. Piperine is one of the best known spicy compounds within this plant. Piperlongumine has been highlighted in experimental research. There has been research carried out to study the antioxidant, anti-inflammatory, antimicrobial and analgesic properties of the plant. When studying isolated compounds, lab research and animal models it is important to note that this does not mean the whole plant would show efficacy or safety to treat disease in humans. [1-3, 6, 8-10, 14, 25, 27, 28]
This review will outline some information regarding the plant’s classification, common names, morphology, and phytochemical groups reported to be present. It will also highlight where there are gaps in the evidence. Each claim made regarding the individual chemicals needs to be verified. It is important to note that just because a compound was found to have some effect in an experiment it does not mean that the whole plant would show this effect. To make detailed recommendations for the cultivation of this plant it would be necessary to consult a specialist source regarding agriculture.
Keywords
Piper longum, Long Pepper, Pippali, Piperine, Phytochemistry, Medicinal Plant, Pharmacological Research.
Full Text:
Download Paper PDF
References
The following list is based on the references supplied with the source manuscript. Some entries use abbreviated author lists or may require bibliographic correction. Verify each item against the original publication before submission.
- Kaushal N, Dahiya DP, Kumari C, Sharma N. A Review: Phytochemical and Pharmacological Properties of Piper longum. International Journal of Pharmaceutical Sciences. 2025;3(10):3385–3393. doi:10.5281/zenodo.17493423.
- Khushboo PS, Jadhav VM, Kadam VJ, Sathe NS. Piperine and piper: An overview of chemistry, pharmacology and pharmacokinetics. International Journal of Pharmaceutical Sciences Review and Research. 2011;5(2):42–46.
- Sunila ES, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. Journal of Ethnopharmacology. 2004;90(2–3):339–346.
- Srinivasan K. Black pepper and its pungent principle—piperine: A review of diverse physiological effects. Critical Reviews in Food Science and Nutrition. 2007;47(8):735–748.
- Tripathi AK, Kohli S, Shukla YN, et al. Phytochemical and pharmacological studies on Piper longum. Journal of Natural Products. 1999;62(3):369–373. Verify title and bibliographic details.
- Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced drug bioavailability by piperine: Evidence that piperine is a potent inhibitor of drug metabolism. Journal of Pharmacology and Experimental Therapeutics. 1985;232(1):258–262.
- Rahman S, Rahmatullah M, et al. Phytochemical and pharmacological review of Piper longum Linn. Journal of Medicinal Plants Studies. 2013;1(5):134–141. Verify full author list and details.
- Bezerra DP, et al. Overview of the therapeutic potential of piplartine (piperlongumine). European Journal of Pharmaceutical Sciences. 2013;48(3):453–463. Verify full author list.
- Raj L, et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011;475(7355):231–234. Verify full author list and DOI.
- Ahmad N, Fazal H, Abbasi BH, Farooq S, Ali M, Khan MA. Phytochemical and pharmacological profile of Piper longum L. Natural Product Research. 2018;32(8):951–960. Verify details.
- Parthasarathy VA, Chempakam B, Zachariah TJ, editors. Chemistry of Spices. CAB International; 2008.
- Parmar VS, Jain SC, Bisht KS, Jain R, Taneja P, Jha A, et al. The chemistry of the genus Piper (Part 1). Phytochemistry. 1997;46(4):597–673.
- Lee SE, Lee BH, Choi WS, Park BS, Kim JG, Campbell BC. Fumigant toxicity of volatile natural products from Korean spices and medicinal plants towards the rice weevil, Sitophilus oryzae. Pest Management Science. 2001;57(6):548–553.
- Tubaro A, Dri P, Delbello G, Zilli C, Della Loggia R. Bioactive amides from Piper longum L. fruits with antinociceptive and anti-inflammatory activities. Planta Medica. 2012;78(15):1582–1587. Verify bibliographic details.
- Hou RC, Huang HM, Tzen JT, Jeng KC. Sesamin induces hepatic fatty acid oxidation and enhances antioxidant capacity in rats. Journal of Agricultural and Food Chemistry. 2003;51(22):6315–6319.
- Majdalawieh AF, Mansour ZR. Sesamol and sesamin: Exemplary phenolic lignans with chemopreventive, anti-inflammatory, and immunomodulatory effects. European Journal of Pharmacology. 2019;815:310–317. Verify year and details.
- Kang JH, Kim H, Kim YH, Lee SH. Antioxidant and anti-inflammatory activities of asarinin isolated from Asarum sieboldii. Archives of Pharmacal Research. 2009;32(7):907–913.
- Hsu DZ, Chen KT, Li YH, Liu MY. Protective effects of asarinin on oxidative stress and inflammation in liver injury. Food and Chemical Toxicology. 2013;59:95–102. Verify details.
- Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. European Journal of Pharmacology. 2008;585(2–3):325–337.
- Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. The Scientific World Journal. 2013;2013:162750.
- Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chinese Medicine. 2010;5:13.
- Khan N, Mukhtar H. Tea polyphenols for health promotion. Life Sciences. 2007;81(7):519–533.
- Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M. A review on the dietary flavonoid kaempferol. Mini Reviews in Medicinal Chemistry. 2011;11(4):298–344.
- Chen AY, Chen YC. A review of the dietary flavonoid, kaempferol, on human health and cancer chemoprevention. Food Chemistry. 2013;138(4):2099–2107.
- Gupta P, et al. Chemical composition and antimicrobial activity of essential oils of Piper longum L. fruits. Journal of Essential Oil Research. 2015;27(5):403–408. Verify full author list and details.
- Kamboj VP. Herbal medicine. Current Science. 2000;78(1):35–39.
- Umar S, et al. Anti-inflammatory and antiarthritic efficacy of Piper longum Linn. in rats. Journal of Ethnopharmacology. 2014;155(1):522–528. Verify full author list.
- Bang JS, et al. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1b-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Research & Therapy. 2009;11:R49. doi:10.1186/ar2662.
- Damanhouri ZA, Ahmad A. A review on therapeutic potential of Piper longum L.: The long pepper. Open Conference Proceedings Journal. 2014;5(Suppl 1):27–32.
- Meena AK, et al. Evaluation of analgesic and antipyretic potential of fruits of Piper longum Linn. International Journal of Pharmaceutical Sciences Review and Research. 2010;5(1):67–70. Verify full author list.
- Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology. 2000;32:S81–S118.
- Bhatia A, et al. Antidiabetic activity of Piper longum in alloxan-induced diabetic rats. Journal of Natural Remedies. 2013;13(1):45–51. Verify full author list and details.
- Platel K, Srinivasan K. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung. 2000;44(1):42–46.
- Dahanukar SA, Thatte UM. Current status of Ayurveda in phytomedicine research. Indian Journal of Pharmacology. 1997;29(6):397–405.
- Royal Botanic Gardens, Kew. Piper longum L. Plants of the World Online. https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:682031-1 (accessed 11 October 2026).
- Sankara Rao K, Swamy RK, Kumar D, Singh A, Bhat KG. Piper longum L. Flora of Peninsular India. Indian Institute of Science; 2019. https://indiaflora-ces.iisc.ac.in/FloraPeninsular/herbsheet.php?cat=7&id;=7082(accessed 11 October 2026).
- Nabi SA, Kasetti RB, Sirasanagandla S, Tilak TK, Kumar MVJ, Rao CA. Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats. BMC Complementary and Alternative Medicine. 2013;13:37. doi:10.1186/1472-6882-13-37.
Share your valuable work from Social Media Buttons