FLAXSEED (LINUM USITATISSIMUM L.) AS A POTENTIAL NATURAL SOURCE OF NIACINAMIDE: EXTRACTION, CHARACTERIZATION AND PHARMACEUTICAL APPLICATIONS

Author

Manisha Ganje,Rinal Panghavane


Abstract

 Flaxseed (Linum usitatissimum L.) is a nutritionally important oilseed containing alpha-linolenic acid, dietary fibre, proteins, lignans, minerals and other bioactive constituents. Vitamin B3, particularly niacinamide or nicotinamide, is an essential water-soluble vitamin involved in cellular metabolism and is widely used in pharmaceutical and cosmetic preparations. Although flaxseed is known to contain niacin and other B-group vitamins, the specific presence and concentration of niacinamide in flaxseed require direct analytical confirmation. This review examines the potential of flaxseed as a herbal source of niacinamide and discusses its botanical characteristics, nutritional composition, biological relevance, extraction, purification, characterization and possible pharmaceutical and cosmetic applications. A proposed workflow includes authentication, cleaning, drying, pulverization, optional defatting, polar solvent extraction, filtration, concentration, purification and chromatographic analysis. Thin-layer chromatography, UV-visible spectroscopy, Fourier-transform infrared spectroscopy and high-performance liquid chromatography may be used as complementary techniques for identification and quantification. Important extraction variables include solvent selection, particle size, solvent-to-sample ratio, temperature, extraction time, pH and extraction cycles. The review highlights the limited flaxseed-specific evidence, the need for validated analytical methods and the importance of experimental confirmation before considering flaxseed an established source of niacinamide. Future research should address optimization, structural confirmation, safety, formulation, stability, scale-up and economic feasibility. and sustainability.



Keywords

Flaxseed, Linum usitatissimum, Niacinamide, Vitamin B3, Extraction, Isolation, Phytochemicals, Nutraceuticals, Antioxidant, Skin Care.



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References


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