Polyherbal Gel Formulation as a Potential Topical Antifungal Agent

Author

Priyanshi Singh,Apurwa A Rewatkar

Abstract

 Superficial fungal infections caused by dermatophytes and Candida species are common and may be associated with recurrence, irritation, and reduced response to conventional antifungal drugs. This has increased interest in plant-derived topical preparations. Neem (Azadirachta indica), tulsi (Ocimum sanctum), and turmeric (Curcuma longa) are medicinal plants with reported antifungal activity. Neem has shown inhibitory effects against dermatophytes and Candida species. Tulsi extracts and essential oil have demonstrated antifungal activity that may be associated with disruption of fungal membrane integrity. Curcumin, the main active constituent of turmeric, has shown anticandidal activity and may affect ergosterol synthesis and fungal virulence factors.

A polyherbal gel containing these three herbs may provide local antifungal action together with anti-inflammatory and antioxidant benefits. Gel formulations are suitable for topical application because they are easy to spread, non-greasy, and can provide local retention of active constituents. Important evaluation parameters include appearance, homogeneity, pH, viscosity, spreadability, extrudability, stability, and in-vitro antifungal activity.

This narrative review synthesizes experimental evidence for neem, tulsi, and turmeric and considers additional studies of herbal gels and hydrogels. A systematic review of tulsi studies and an in-vitro Curcuma study support further antifungal investigation, while related gel studies illustrate useful formulation and safety assessments. The findings remain preliminary: the specific neem-tulsi-turmeric gel has not been clinically validated, and extract standardization, compatibility, stability, skin safety, and comparative antifungal testing are required.

Keywords

Polyherbal gel, Topical antifungal, Antifungal agent, Herbal formulation, Mycosis , Antimicrobial activity, Topical drug delivery

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References

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