Antipsychotic Therapy: Pharmacology, Efficacy and Safety

Author

Dr. S.Indu Harini, Gedala.Mayuri, Jonnapalli.Yaswanth.


Abstract

 Conventional and Atypical Antipsychotic Drugs For more than fifty years, conventional (first-generation) antipsychotic drugs have been widely used to manage a variety of serious psychiatric illnesses. In recent years, these medications have been increasingly replaced by newer or second-generation (atypical) antipsychotics, the development of newer agents was strongly influenced by landmark study published in 1998, including aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and ziprasidone.therapeutic efficacy, safety profile, adverse effects, and cost of both conventional and atypical antipsychotic drugs. Since the differences in effectiveness and tolerability between many of these medications are relatively small,and some newer agents are associated with important long-term metabolic risks, both first- and second-generation antipsychotics continue to have an important place in clinical practice. Therefore, treatment decisions should be based on each patient's clinical condition, potential benefits, possible risks, and treatment costs.



Keywords

Antipsychotic drugs, schizophrenia, chlorpromazine, brexpiprazole, dopamine, serotonin, D₂ receptor, adverse effects.



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