BIODEGRADABLE POLYMERS FOR ADVANCED DRUG DELIVERY: APPLICATIONS, CHALLENGES AND FUTURE PERSPECTIVES

Author

H. Divya, Dr. Pisipati Aparna, Dr. Y A Chowdary


Abstract

 Biodegradable polymers in pharmaceutical and biomedical technologies are a new generation of materials that offer many advantages. This characteristic feature of polymers is their ability to degrade into harmless products that can be removed or absorbed by the body. Unlike nondegradable polymers, biodegradable polymers are widely used in drug delivery systems because they allow the implementation of various forms of controlled drug release. 

The article presents the concepts and characteristics of polymers, the history of their development, and areas of application. The article answers the questions of how and why polymers were created, what properties and advantages they have, and which industries use them. This review covers natural and synthetic polymers, including polylactic acid, poly(lacticco-glycolic acid), polycaprolactone, polyhydroxyalkanoates, chitosan, sodium alginate, gelatin, cellulose derivatives, and related compounds. They are used in the controlled and targeted delivery of drugs, including nanoparticle and microparticle forms, hydrogels, biodegradable implants, pharmaceutical coatings, mucoadhesive and transmucosal drug delivery systems, 3D-printed drug delivery systems, tissue engineering, and wound healing. The article also addresses the challenges and prospects of biodegradable polymers, including polymer modification strategies, smart nanocarriers, and targeted and triggered drug delivery. Moreover, the factors affecting the biodegradation of polymers are discussed, including the chemical structure of the material, its molecular weight, and other properties: crystallinity, morphology, hydrophobicity, and more. Factors such as processing, sterilization, storage, and environmental conditions are also important aspects of biodegradable polymers. Moreover, the authors explore the issues of cost, inconsistent drug release, variable drug loading, inadequate storage, and scalability. The future of biodegradable polymers depends on several key factors, including research into new materials, smart polymers, and nanotechnology, standardization of biodegradation tests, and optimization of processes and technologies for degrading polymers, reducing microplastics, and sustainable production and recycling of materials



Keywords

Biodegradable polymers; Natural polymers; controlled drug release; pharmaceutical applications; Nanoparticles



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References


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