Green and Rapid Synthesis of 3-Methyl-1-Phenyl-5-Pyrazolone and Its Derivatives via an Efficient Approach

Author

Neha Ajay Pandey


Abstract

 The synthesis of 3-methyl-1-phenyl-5-pyrazolone [PMP] had been performed in very simplest way by heating the mixture of phenyl hydrazine and ethyl acetoacetate, on cooling addition of ether, then recrystallize by aqueous ethanol. These experiments taken place in small and large amount to get the required amount of products. Treatment of a mixture of 3-methyl-1-phenyl-5-pyrazolone [PMP] with benzaldehyde derivatives in absolute ethanol results in fast (5 min) formation of 4,4’-(arylmethylene) bis-(1H-pyrazol-5-ol) and their derivatives in excellent yield. The reaction conditions such as solvent, temperature, and reaction time have been optimized to obtain high yields of the desired products. synthesized compounds have been further characterised using various spectroscopic techniques such as IR ,NMR, and Mass spectroscopy. All synthesized compounds were evaluated for antioxidant activity by the N, N-diphenyl-N’-picrylhydrazyl (DPPH). These are catalyst-free tandem Knoevenagel-Michael reactions, pure products were isolated by simple filtration.   4,4’-( Arylmethylene ) bis -(1H-pyrazol-5-ol) and it’s derivatives are important compounds with biological and industrial applications.



Keywords

3-methyl-1-phenyl-5-pyrazolone [PMP] , 4,4’-( arylmethylene ) bis-(1H-pyrazol-5-ol), DPPH



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Research Papers:

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