Dr. Nasser Thallaj


Biological mimicry of the oxidation process of the active sites of iron proteins leads to the formation of peroxides, specifically oxygenated water, where the latter is a strong and highly satisfactory oxidizing agent, characterized by non-toxicity and low cost. In many cases, nature employs molecular oxygen for oxidative processes, particularly under extenuating conditions. Iron complexes with tris(2-pyridylmethyl)amine ligands have been studied to mimic the biologically active sites and prove their vital importance.This paper studies the possibility of obtaining iron(II) complexes with aromatic bonds of the tri-type (2-pyridylmethyl)amine on the alpha site of the nitrogen atom with testing the activity towards molecular oxygen for one complex selected from the synthesized complexes.


Biomimetics, tri (2-pyridylmethyl)amine, activation of molecular oxygen, iron(II).

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  1. A SHORT COURSE. ROAT-MALONE, R.M., Bioinorganic Chemistry : Wiley Interscience. 2002, P45.
  2. Malek, Z.S.; Sage D.; Pevet, P.; Raison, S.; Endocrinology 2007, 148 (11), 5165-5173
  3. Malek, Z.S.; Dardente, H.; Pevet, P.; Raison, S.; European Journal of Neuroscience 2005, 22 (4), 895-901.
  4. Malek, Z.S.; Pevet, P.; Raison, S.; Neuroscience 2004, 125 (3), 749-758.
  5. Malek, Z.S.; Labban, L.; The International Journal of Neuroscience, 2020, 1-7.
  6. Malek, Z.S.; Labban, L.; European Journal of Pharmaceutical and Medical Research 2019, 6 (11), 527-532.
  7. Malek, Z.S.;  Journal of AlBaath University 2018, 40 (4), 39-62
  8. Malek, Z.S.; Tishreen University Journal for Research and Scientific Studies, 2018, 40
  9. -Makhlynets OV, Oloo WN, Moroz YS, Belaya IG, Palluccio TD, Filatov AS, Müller P, Cranswick MA, Que L Jr, Rybak-Akimova EV.Chem Commun (Camb). 2014 Jan 21;50(6):645-8. P645-646. 
  10. SOLOMON, E. I., BRUNOLD, T. C., DAVIS, M. I., KEMSLEY, J. N., LEE, S. K., LEHNERT, N.,   NEESE, F., SKULAN, A. J., YANG, Y. S., ZHOU, J., Chem. Rev., 100, 235-349, 2000,P235-236.
  11. Iyer SR, Javadi MM, Feng Y, Hyun MY, Oloo WN, Kim C, Que L Jr.Chem Commun (Camb). 2014 Nov 18;50(89):13777-80.P 13777-13778-13779 
  12. Coordination Chemistry Reviews 200-202, 443-485, 2000,P443-444-445.
  13. KRYATOV, S.V., RYBAK-AKIMOVA, E.V., MMACMURDO, V.L., QUE, L.JR., Inorg Chem  40, 2220-2228, 2001,P2220-2221 
  14. Kleespies ST, Oloo WN, Mukherjee A, Que L Jr. Inorg Chem. 2015 Jun 1;54(11):5053-64. P5053-5054-50555 
  15. Oloo WN, Que L Jr.Acc Chem Res. 2015 Sep 15;48(9):2612-21. doi: 10.1021/acs.accounts.5b00053. Epub 2015 Aug 17.
  16. Prakash J, Rohde GT, Meier KK, Münck E, Que L Jr.Inorg Chem. 2015 Dec 7;54(23):11055-7.P11055-11056.
  17. Prakash J, Que L. Chem Commun (Camb). 2016 Jun 21;52(52):8146-8. P 8147-8148.
  18. Klein JE, Dereli B, Que L, Cramer CJ. Chem Commun (Camb). 2016 Aug 18;52(69):10509-12.P10509-10510.
  19. MICHAEL P .JENSEN ,STEVEN J.LANGE, MARK, EMILY L.que And Lawrence Que , Jr. JACS , 125, 2113-2128, 2003,P2113-2114
  20. LEHNERT, N., HO, R.Y.N., QUE, L.JR., SOLOMON, E.I., J. Am Chem Soc., 123, 8271-8290, 2001, P8271-8272-8273-8274.
  21. COSTAS, M., TIPTON A.K., CHEN, K., JO, D.H., QUE, L.JR, J. Am Chem Soc., 123, 6722-6723, 2001, P6722.
  22. JO, D.H., CHIOU, Y.M., QUE, L.JR., J.Am.Chem.Soc., 40, 3181-3190, 2001,P3181-3182.
  23. CHIOU, Y.M., QUE, L.JR., J.Am.Chem.Soc., 117, 3999-4013, 1995, P3999-4001-4002-4003.
  24. ZANG, Y., QUE, L.,JR., Inorg Chem  34, 1030-1035, 1995,P1030-1031.
  25. MANDON, D., MACHKOUR, A., GOETZ, S., WELTER, R., Inorg. Chem Vol.41,No.21, 41, 5364–5372, 2002., P5364-5365-5366-5367.
  26. MACHKOUR, A., MANDAON, D., WELTER, R.,  Inorg. Chim. Acta, 358, 839–843, 2005, P840-841.
  27. MIYAURA, N., YANAGI, T., SUSUKI, A., SYNTH. Commun, 11(7), 513-519, 1981, P514-515.
  28. -Machkour A, Thallaj NK, Benhamou L, Lachkar M, Mandon D.Chemistry. 2006 Aug 25;12(25):6660-8.P 6660-6661-6662-6663.
  29. Thallaj, N., Machkour, A., Mandon, D., Welter, R., New. J. Chem., 2005, 29, 1555 – 1558.
  30. Thallaj, N. K. Damascus University Journal for Basic Sciences. 34 (1) 2018.
  31. Thallaj. N. K. Journal of AlBaath University (39) 2017. 
  32. Thallaj. N. K. Tishreen University Journal for Research and Scientific Studies 38 (6) 2016. 
  33. Thallaj NK, Rotthaus O, Benhamou L, Humbert N, Elhabiri M, Lachkar M, Welter R, Albrecht-Gary AM, Mandon D. Chemistry. 2008;14(22):6742-53.P6745-6746-6747..
  34. Wane A, Thallaj NK, Mandon D. Chemistry. 2009 Oct 12;15(40):10593-602. P10594-10595-10595.
  35.  Thallaj NK, Orain PY, Thibon A, Sandroni M, Welter R, Mandon D. Inorg Chem. 2014 Aug 4;53(15):7824-36. P7826-7827-7828.
  36. N. K. Thallaj, J. Przybilla, R. Welter and D. Mandon, J. Am. Chem. Soc. 2008, 130, 2414-2415.  
  37. N. K. Thallaj, D. Mandon and K. A. White, Eur. J. of Inorg. Chem., 2007, 44–47. 
  38. N. K. Thallaj, A. Machkour, D. Mandon and R. Welter, New J. Chem., 2005, 29, 1555–1558.
  39. Thallaj, N.; International journal of applied chemistry and biological sciences 2021, 2 (4), 65-77.
  40. Thallaj, N.; Indian Journal of Advanced Chemistry (IJAC)2021, 1 (2), .
  41. DA MOTA, M. M.; RODGERS, J.; NELSON, S. M.; J. Chem. Soc. (A). 1969, 2036-2044, P2040-2042.
  42. Jaafar H, Vileno B, Thibon A, Mandon D. Dalton Trans. 2011 Jan 7;40(1):92-106.P 92-93-94-95-96.
  43. -Benhamou L, Thibon A, Brelot L, Lachkar M, Mandon D. Dalton Trans. 2012 Dec 21;41(47):14369-80.P14369-14370-14371-14372.
  44. BERTINI, I., LUCHINAT, C., PARIGI, G., Solution RMN paramagnetic Molecules. Current Methods in inorganic chemistry, Vol 2, Elsevier, 2001, P14-22, 34-39, 67-98.
  45. TYEKLAR, Z.; JACOBSON, R. R.; WEI, N.; MURTHY, N. M.; ZUBIETA, J AND KARLIN, K. D.; J. AM. Chem. Soc. 1993, 115, 2677-2689, P2681-2682,2683.
  46. NELSON, M. S.; RODGERS, J.; J. Chem. Soc. (A). 272-276, 1968, P272-273-274.
  47. V. CAPRIO, J. MANN, J. Chem. Soc., Perkin Trans. 1, 3151–3155, 1998,P3152-3153.
  48. R T. SHUMAN, P.L. ORNSTEIN, J. W. PASCHAL,  P.D. GESELLCHEN, J. ORG. Chem. 55, 738-741, 1990,P739.

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